The Cleft Collective cohort studies investigates the biological and environmental causes of cleft, the best treatments for cleft and the impact of cleft on those affected and their families.
Our research will help answer three key questions that families ask:
What has caused my child’s cleft?
What are the best treatments for my child?
Will my child be OK (both now and in the longer term)?

Using Cleft Collective’s Data
The Cleft Collective is a large-scale multigenerational cohort study of children born with cleft lip and/or palate (CL/P). More than 3300 families have been recruited from all 16 CL/P regional NHS clinical centres since 2013; they have contributed biological samples, completed questionnaires as well as speech and language assessments across various time points. Furthermore, with parents’ consent, the Cleft Collective has accessed medical and educational records through data linkage. This resource has been established to provide data from multiple disciplines with the aim of answering your research questions relating to cleft.

The Cleft Collective website details how you can access the resource. The data access policy, research proposal form and a data dictionary detailing the data which is currently available are all accessible via the website. Please do contact the Cleft Collective directly at email: cleft-collective@bristol.ac.uk to discuss your research question further as the team is there to support you in any way they can. Where appropriate, they may also be able to discuss the potential of setting up a nested study with you, where new data is collected on a subsample of the cohort.

We encourage collaborators from all disciplines across the world to apply to use the resource.

Details of staff:

Name: Dr Yvonne Wren
Job Title: CI of The Cleft Collective
Address: University of Bristol
Phone: +44 0117 3310025
Mail: yvonne.wren@bristol.ac.uk

Name: Ms Kerry Humphries
Job Title: Project Manager of The Cleft Collective
Contact Details: University of Bristol
Phone: +44 0117 3310025
Mail: k.humphries@bristol.ac.uk

Name: Miss Amy Davies
Job Title: Research Coordinator
Contact Details: University of Bristol
Phone: +44 0117 3310025
Mail: A.Davies@bristol.ac.uk

Name: Professor Sarah Lewis
Job Title: Professor of Molecular Epidemiology
Contact Details: University of Bristol
Phone: +44 0117 3310025
Mail: S.J.Lewis@bristol.ac.uk

Name: Dr Gemma Sharp
Job Title: Senior Lecturer in Molecular Epidemiology
Contact Details: University of Bristol
Phone: +44 0117 3310025
Mail: Gemma.Sharp@bristol.ac.uk

Details About Research: Publications by members of The Cleft Collective team and collaborators using Cleft Collective data can be found here:
http://www.bristol.ac.uk/cleft-collective/professionals/publications/

References for Research:

List of publications
http://www.bristol.ac.uk/cleft-collective/professionals/publications/