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No. of Cases Seen in a Year

• Total Referrals: 60
• Unilateral cleft lip and palate: 24
• Bilateral cleft lip and palate: 9
• Cleft palate only: 27
• Pierre Robin Sequence: 5
• With anomalies present: 5

Treatment Funded by State for National Residents

• Surgery costs: All
• Speech and Language Therapy costs: All
• Orthodontic costs: All

Primary surgical protocol

Cleft Lip Repair:

• Timing: 6 months
• Type of operation: Lip and nose repair - Tennison- Mc Comb technique

Bilateral Cleft Lip Repair:

• Timing: 6 months
• Type of operation: lip repair and colummelar lengthening - Manchester technique and open rhinoplasty

Cleft Palate Repair:

• Stages: Two stage
• 1st Stage Timing: 3 months
• 1st Stage Type of operation: Soft palate repair - Widmaier technique
• 2nd Stage Timing: 18 months
• 2nd Stage Type of operation: Hard palate closure (two layers), or complete closure (Von Langebeck technique)

Record collection protocol

Are records routinely collected at specific ages? Yes

Does this conform to WHO recommendations for different cleft types? Yes

Research

Want to particpate in research? yes

Participation in inter-centre studies?

Current Research

Clinical research activities interested in being involved in:

Randomised clinical trials:	Yes
Inter-centre comparison of outcome:	Yes
DNA collection:	Yes

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Clinical research

Clinical team members who are or would like to be involved in clinical research:
Member details: Ugo Baciliero - surgery - inter center
Manuela Riga - surgery - inter center
Flavia Nardi - speech therapy - inter center
Rossella Borgo - nursery - cohort

EU Biobank

Stored CLP DNA samples available for use in future studies:
Number for CP: 40
Number for CLP: 230

Potential laboratory based research activities

Laboratory based research activities interested in being involved in:
Laboratory genetics/genomics research: Yes